A simple synthesis of 1-aminophosphonic acids from 1-hydroxyiminophosphonates with NaBH4 in the presence of transition metal compounds

DOI: 10.1016/0040-4039(95)02171-X

Source and publish data:

Tetrahedron Letters p. 407 - 410 (1996)

Update date:2022-08-04

Topics:

Authors:

Demir, Ayhan S.

Tanyeli, Cihangir

Sesenoglu, Oezge

Demic, Serafettin

Evin, Oezden Oezel

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Article abstract of DOI:10.1016/0040-4039(95)02171-X

A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminophosphonates when treated with hydroxylamine hydrochloride. Reduction of hydroiminophosphonates with NaBH₄ in MeOH in the presence of MoO₃ or NiCl₂ and hydrolysis of 1-aminophosphonates gave 1-aminophosphonic acids in good yields.

Full text of DOI:10.1016/0040-4039(95)02171-X

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