A simple synthesis of 1-aminophosphonic acids from 1-hydroxyiminophosphonates with NaBH4 in the presence of transition metal compounds

DOI: 10.1016/0040-4039(95)02171-X

Source and publish data:

Tetrahedron Letters p. 407 - 410 (1996)

Update date:2022-08-04

Topics:

Authors:

Demir, Ayhan S.

Tanyeli, Cihangir

Sesenoglu, Oezge

Demic, Serafettin

Evin, Oezden Oezel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)02171-X

A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminophosphonates when treated with hydroxylamine hydrochloride. Reduction of hydroiminophosphonates with NaBH₄ in MeOH in the presence of MoO₃ or NiCl₂ and hydrolysis of 1-aminophosphonates gave 1-aminophosphonic acids in good yields.

Full text of DOI:10.1016/0040-4039(95)02171-X

Products guided by the article

Product name:[Amino-(2,4-dimethyl-phenyl)-methyl]-phosphonic acid diethyl ester

Cas No:174737-67-8

R&D Labs maybe for 174737-67-8

Jiaxing Trustworthy Import And Export Co.,Ltd

Contact:+86-573-82030555

Address:Room 1202, Unit B, Charming plaza,No.1558 East Zhongshan Road , Jiaxing City, Zhejiang Province, China.
Shanghai Mokai Pharmaceutical Co.,Ltd

Contact:021-60257269

Address:Rm506,No.915,Zhenbei Road,Shanghai,200333,China
Hangzhou jls Flame Retardants Chemical Co.,Ltd

Contact:+86-571-87250387/87250386

Address:MOGANSHAN RODA 1418# SHANGCHENG INDUSTRIAL PARK
Shanghai Korey Pharm Co.,Ltd.(expird)

Contact:021-61840961 021-61840962

Address:No.157,Zhuguang Rd, Qingpu, Shanghai, China
VanderArk International Limited

Contact:86-10-82437576

Address:Qing He

Relevant to this article

Synthesis of proline analogues as potent and selective cathepsin S inhibitors

Doi:10.1016/j.bmcl.2013.04.023
(2013)
Synthesis of chiral allylic thioesters: Enantio- and regioselective iridium-catalyzed allylations of KSAc

Doi:10.1002/ejoc.201201640
(2013)
Synthesis and properties of some gallium amidine complexes [GaX_yL_3-y] [X = Me, Et or Cl; L = RNCR′NR (R, R′ = H, alkyl or aryl); y = 0-2]. Crystal structures of [GaMe₂(PhNCPhNPh)] and [GaMe-(PhNCPhNPh)₂]

Doi:10.1039/DT9960000431
(1996)
Novel 6-substituted 2-aminotetralins with potent and selective affinity for the dopamine D₃ receptor

Doi:10.1016/0960-894X(96)00043-1
(1996)
Synthesis of enantiopure 1,2-didehydropyrrolidine, D-proline, and oxazoline derivatives via Staudinger-aza-Wittig cyclization of γ-azido aldehydes

Doi:10.1055/s-1996-4162
(1996)
3. Compounding selectivity in reactions of diastereoisomeric radical intermediates: An experimental demonstration that the yield of a product from a diastereotopic-group-selective reaction can significantly exceed the level of group selectivity

Doi:10.1002/hlca.19960790104
(1996)

Article Doi