Highly potent and selective inhibitors of endothelin converting enzyme

DOI: 10.1016/0960-894X(96)00211-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1257 - 1260 (1996)

Update date:2022-09-26

Topics:

Authors:

Chackalamannil, Samuel

Chung, Shin

Stamford, Andrew W.

McKittrick, Brian A.

Wang, Yuguang

Tsai, Hsingan

Cleven, Renee

Fawzi, Ahmad

Czarniecki, Michael

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00211-9

Phosphinic acid derivatives, represented by structure 1, have been synthesized and evaluated as endothelin convening enzyme (ECE) inhibitors. Several of these compounds (for example, 1b, 1c, and 1f) were found to be potent inhibitors of ECE with a high degree of selectivity against neutral endopeptidase (NEP).

Full text of DOI:10.1016/0960-894X(96)00211-9

Products guided by the article

Product name:4-Methyl-2-methylene-pentanoic acid 3,4-dimethoxy-benzyl ester

Cas No:174767-45-4

R&D Labs maybe for 174767-45-4

Henan PURUI Pharmaceutical Co., Ltd.

website:http://www.puruipharm.com

Contact:17739583555

Address:Yezhuangqiao,Xihua town, Henan province
Jiangsu Wanlong Chemical Co., Ltd.

website:http://www.wanlongchem.com

Contact:+86-511-86810993 0086-511-8681 0888;

Address:Quanzhou Town, Danyang City, Jiangsu
HANGZHOU YUNUO CHEMICAL CO.,LTD

website:http://www.yunuochem.com

Contact:0571-83715115

Address:hangzhou
Xi'an Herbland Tech Inc.

Contact:+86-29-88710656

Address:South Tai bai Road, High Tech Development Zone, Xi'an China
SHIJIAZHUANG CHENSHI IMPORT AND EXPORT CO.,LTD

Contact:+86-311-89871056

Address:RM2017 BUILDING CTIANSHAN GALAXY PLAZA,NO168 CHANGJIANG ROAD,GAOXIN DISTRICT,SHIJIAZHUANG CITY, HEBEI,CHINA

Relevant to this article

Diastereomerically pure pyrrolidin-2-ones by intramolecular Michael reaction. Synthesis of both (S)- and (R)-3-pyrrolidineacetic acid

Doi:10.1016/0957-4166(95)00423-8
(1996)
Synthesis and chemistry of unusual bicyclic endoperoxides containing the pyridazine ring

Doi:10.1021/jo0345300
(2003)
Insertion of ethyne into the Ru-Si bonds of coordinatively unsaturated ruthenium silyl complexes. X-ray crystal structures of Ru(CH=CHSiMe₂OEt)Cl(CO)₂(PPh₃)₂ and [Ru(CH=CHSiMe₂OH)(CN-p-tolyl)(CO)(PPh₃) ₂]ClO₄

Doi:10.1021/om9509711
(1996)
The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists

Doi:10.1002/jccs.199600014
(1996)
Studies on selectin binding inhibitors: Synthesis of sialyl-Lewis X and sialyl-Lewis a epitope analogs containing 2-acetamido derivative of N-methyl-1-deoxynojirimycin

Doi:10.1080/07328309608005420
(1996)
A Bioinspired Catalytic Aerobic Oxidative C-H Functionalization of Primary Aliphatic Amines: Synthesis of 1,2-Disubstituted Benzimidazoles

Doi:10.1002/chem.201502487
(2015)

Article Doi