Bioorganic and Medicinal Chemistry Letters p. 1257 - 1260 (1996)
Update date:2022-09-26
Topics:
Chackalamannil, Samuel
Chung, Shin
Stamford, Andrew W.
McKittrick, Brian A.
Wang, Yuguang
Tsai, Hsingan
Cleven, Renee
Fawzi, Ahmad
Czarniecki, Michael
Phosphinic acid derivatives, represented by structure 1, have been synthesized and evaluated as endothelin convening enzyme (ECE) inhibitors. Several of these compounds (for example, 1b, 1c, and 1f) were found to be potent inhibitors of ECE with a high degree of selectivity against neutral endopeptidase (NEP).
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Doi:10.1016/0957-4166(95)00423-8
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