Highly potent and selective inhibitors of endothelin converting enzyme

DOI: 10.1016/0960-894X(96)00211-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1257 - 1260 (1996)

Update date:2022-09-26

Topics:

Authors:

Chackalamannil, Samuel

Chung, Shin

Stamford, Andrew W.

McKittrick, Brian A.

Wang, Yuguang

Tsai, Hsingan

Cleven, Renee

Fawzi, Ahmad

Czarniecki, Michael

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Article abstract of DOI:10.1016/0960-894X(96)00211-9

Phosphinic acid derivatives, represented by structure 1, have been synthesized and evaluated as endothelin convening enzyme (ECE) inhibitors. Several of these compounds (for example, 1b, 1c, and 1f) were found to be potent inhibitors of ECE with a high degree of selectivity against neutral endopeptidase (NEP).

Full text of DOI:10.1016/0960-894X(96)00211-9

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