
Chemical and Pharmaceutical Bulletin p. 252 - 254 (1996)
Update date:2022-08-03
Topics:
Miyashita
Suzuki
Okumura
Higashino
The treatment of 2-benzyl-1,2-diphenyl-2-hydroxyethanone (3a, benzylbenzoin) with potassium cyanide in DMF gave deoxybenzoin (4a). The formation of deoxybenzoin (4a) proceeds through retro-benzoin condensation by catalytic action of cyanide ion. Similarly, retro-benzoin condensation applied to several substituted benzoins 3 resulted in the formation of the corresponding ketones 4 in excellent yields.
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