Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

DOI: 10.1016/0960-894X(96)00001-7

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Bioorganic and Medicinal Chemistry Letters p. 253 - 258 (1996)

Update date:2022-08-02

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Authors:

Verbruggen, Christophe

De Craecker, Sofie

Rajan, Padinchare

Jiao, Xian-Yun

Borloo, Marianne

Smith, Keith

Fairlamb, Alan H.

Haemers, Achiel

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Article abstract of DOI:10.1016/0960-894X(96)00001-7

A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity. Copyright

Full text of DOI:10.1016/0960-894X(96)00001-7

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