Chiral synthesis of phosphodiesterase inhibitor, (R)-(-)-rolipram, by means of enantioselective deprotonation strategy

DOI: 10.3987/COM-95-S33

Source and publish data:

Heterocycles p. 109 - 112 (1996)

Update date:2022-07-31

Topics:

Authors:

Honda, Toshio

Ishikawa, Fumihiro

Kanai, Kazuo

Sato, Shigeki

Kato, Daishiro

Tominaga, Hideo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.3987/COM-95-S33

Enantioselective synthesis of the antidepressant (R)-(-)-rolipram (1) has been achieved by using an enantioselective deprotonation of the cyclobutanone derivative as a key step.

Full text of DOI:10.3987/COM-95-S33

Products guided by the article

Product name:2-Cyclopentyloxy-1-methoxy-4-vinyl-benzene

Cas No:175165-63-6

R&D Labs maybe for 175165-63-6

KangZhiYuan Pharmaceutical Company Limited

Contact:(Sabrina)86-20-85273232

Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Shandong LuZhou Amino Acid Co., Ltd

Contact:86-539-2218025

Address:yishui economic and technical development zone zhenxing south road
Jinan Boss Chemical Industry Co., Ltd.【revoke the business license】

website:http://www.chemboss.com.cn

Contact:+86-531-58591595

Address:No2.Hualong Road, Jinan, China
Taizhou Huading Chemical Co.,Ltd(expird)

Contact:+86-576-88583898

Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Shijiazhuang Haotian Chemical Co., Ltd.

Contact:86-311-85044374

Address:293 Donggang Road

Relevant to this article

Nucleosides and nucleotides. 147. Synthesis of DNA dodecamers containing oxetanocin A and (2R, 3R)-2-C-(adenin-9-yl)-1,4-anhydro-2,3-dideoxy-3-C-hydroxymethyl-D-arabitol

Doi:10.1016/0040-4020(96)00007-5
(1996)
Vinyl fluoride as a mimic of the 'intermediate' enol form in the 5α-reductase transformation: Synthesis and in vitro activity of (N-1′,1′-dimethylethyl)-3-haloandrost-3,5-diene-17β- carboxamides

Doi:10.1016/0968-0896(95)00160-3
(1996)
Asymmetric synthesis of chiral spirocyclanes: A new route to the optically active spiro[cyclopentane-1,1′-indan]-2,5-dione system

Doi:10.1016/0040-4039(96)00126-8
(1996)
Facile Synthesis, Triplet-State Properties, and Electrochemistry of Hexaiodo-Subphthalocyanine

Doi:10.1002/chem.201803316
(2018)
15. Total synthesis of (+)-elacomine and (-)-isoelacomine, two hitherto unnamed oxindole alkaloids from Elaeagnus commutata

Doi:10.1002/hlca.19960790116
(1996)
Synthesis, structure, and properties of the stahle and highly acidic dihydrogen complex trans-[Os(η²-H₂)(CH₃CN)(dppe) ₂](BF₄)₂. Perspectives on the influence of the trans ligand on the chemistry of the dihydrogen ligand

Doi:10.1021/om960113k
(1996)

Article Doi