Chiral synthesis of phosphodiesterase inhibitor, (R)-(-)-rolipram, by means of enantioselective deprotonation strategy

DOI: 10.3987/COM-95-S33

Source and publish data:

Heterocycles p. 109 - 112 (1996)

Update date:2022-07-31

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Authors:

Honda, Toshio

Ishikawa, Fumihiro

Kanai, Kazuo

Sato, Shigeki

Kato, Daishiro

Tominaga, Hideo

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Article abstract of DOI:10.3987/COM-95-S33

Enantioselective synthesis of the antidepressant (R)-(-)-rolipram (1) has been achieved by using an enantioselective deprotonation of the cyclobutanone derivative as a key step.

Full text of DOI:10.3987/COM-95-S33

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