An improved synthesis of azidothymidine

Article abstract of DOI:10.1080/07328319608002136

A convenient and high yielding procedure is described for a direct conversion of thymidine (1) into 2,3'-anhydrothymidine (2) using the Mitsunobu reaction. Isolation and characterization of two new compounds, 3 and 4, are discussed. AZT has been synthesized from 1 in two steps, in 62% overall yield, by heating 2 with NaN₃ in DMF.

Full text of DOI:10.1080/07328319608002136

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Nucleosides and Nucleotides
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An Improved Synthesis of
Azidothymidine
M. I. Balagopala a , A. P. Ollapally a & H. J. Lee b
a Department of Chemistry, Florida A &M University, Tallahassee,
FL, 32307.
b College of Pharmacy and Pharmaceutical Sciences, Florida A
&M University, Tallahassee, FL, 32307
Version of record first published: 20 Aug 2006.
To cite this article: M. I. Balagopala , A. P. Ollapally & H. J. Lee (1996): An Improved Synthesis of
Azidothymidine, Nucleosides and Nucleotides, 15:4, 899-906
To link to this article: http://dx.doi.org/10.1080/07328319608002136
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