2-[(Alkylsulfonyl)oxy]-6-substituted-1H-isoindole-1,3(2H)-dione mechanism-based inhibitors of human leukocyte elastase

DOI: 10.1016/0960-894X(96)00038-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 451 - 456 (1996)

Update date:2022-07-30

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Authors:

Kerrigan, John E.

Shirley, Jennifer J.

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Article abstract of DOI:10.1016/0960-894X(96)00038-8

Derivatives of 2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3(2H)-diones (N-sulfonyloxy)phthalimides) with ring substituents in the 6-position were found to exhibit enhanced inhibitory potency and selectivity for HLE. The most potent inhibitor of HLE in this ser

Full text of DOI:10.1016/0960-894X(96)00038-8

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