Preparation and antirheumatic activity of optically active 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298)

DOI: 10.1248/cpb.44.602

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 602 - 604 (1996)

Update date:2022-07-31

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Authors:

Kameo, Kazuya

Takeshita, Kimiyo

Yasuda, Yoshiko

Matsumoto, Keita

Tomisawa, Kazuyuki

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Article abstract of DOI:10.1248/cpb.44.602

2-Acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanonic acid (KE-298) is an antirheumatic agent. To elucidate the effects of optically active KE-298, we resolved the racemic acid and obtained the two optical isomers. ( + )-KE-298 was converted to the 4-bromo

Full text of DOI:10.1248/cpb.44.602

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