A N-nitrosochloroethyl-cephalosporin carbamate prodrug for antibody-directed enzyme prodrug therapy (ADEPT)

DOI: 10.1016/0040-4020(96)00228-1

Source and publish data:

Tetrahedron p. 5983 - 5988 (1996)

Update date:2022-08-04

Topics:

Authors:

Alexander, Rikki P.

Bates, Robert W.

Pratt, Andrew J.

Kraunsoe, James A. E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4020(96)00228-1

N-nitrosochloroethyl-cephem 7 was prepared via acylation and selective nitrosation of a cephalothin derivative. This cephalosporin is an efficient substrate for Enterobacter cloacae P99 β-lactamase. Kinetic parameters were determined for enzyme-catalysed hydrolysis. This cephalosporin is a potential prodrug for the delivery of bis-alkylating chloroethyldiazo species to tumours by antibody-β-lactamase conjugates.

Full text of DOI:10.1016/0040-4020(96)00228-1

Products guided by the article

Product name:(6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Cas No:176518-99-3

R&D Labs maybe for 176518-99-3

Jinan Trio PharmaTech Co., Ltd

Contact:86-531-88811783；+(0)13153010282

Address:2766 Yingxiu Road, Jinan High-Tech Zone, China
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.

Contact:0086-0576-88551200,88886292 ,88880039

Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China
Hangzhou TJM Chemical Trade Co., Ltd

Contact:86-571-88223276 86-13388481653

Address:2221#,Boyuexuan,1860# Binsheng Road,Binjiang District, Hangzhou CityZhejiang Province, 310051, P. R. China
Sigma-Aldrich Chemie GmbH

website:http://www.sigmaaldrich.com

Contact:800 558-9160

Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland
Lyrin Industrial Corporation Limited

Contact:86-731-82571800

Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China

Relevant to this article

Synthesis of (1R)-(+)-nopinone- and (1S)-(-)-verbenone-derived chiral annulated indenes via electrocyclic reactions

Doi:10.1016/0040-4039(96)01629-2
(1996)
New prolyl endopeptidase inhibitors: In vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives

Doi:10.1021/jm950858c
(1996)
Amidoalkylation of Sulfonylheteroarenes with Alkylamides through a Radical Chain Mechanism

Doi:10.1002/ejoc.202001457
(2021)
Enantiospecific synthesis of cyanocyclitols and (6R)-6-hydroxyshikimic acid from benzonitrile

Doi:10.1016/0957-4166(96)00055-9
(1996)
Reactions of [RuCp(EPh₃)₂Cl] {E = P, As, Sb} with Ni(II) complexes of N-cyanodithiocarbimate anions bearing pendant donor groups

Doi:10.1080/00945719608004761
(1996)
Studied directed toward the synthesis of phomenoic acid. Part 2. Stereocontrolled synthesis of the C(7)-to-C(14) segment

Doi:10.1002/hlca.19960790219
(1996)

Article Doi