Tetrahedron p. 5983 - 5988 (1996)
Update date:2022-08-04
Topics:
Alexander, Rikki P.
Bates, Robert W.
Pratt, Andrew J.
Kraunsoe, James A. E.
N-nitrosochloroethyl-cephem 7 was prepared via acylation and selective nitrosation of a cephalothin derivative. This cephalosporin is an efficient substrate for Enterobacter cloacae P99 β-lactamase. Kinetic parameters were determined for enzyme-catalysed hydrolysis. This cephalosporin is a potential prodrug for the delivery of bis-alkylating chloroethyldiazo species to tumours by antibody-β-lactamase conjugates.
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Doi:10.1016/0040-4039(96)01629-2
(1996)Doi:10.1021/jm950858c
(1996)Doi:10.1002/ejoc.202001457
(2021)Doi:10.1016/0957-4166(96)00055-9
(1996)Doi:10.1080/00945719608004761
(1996)Doi:10.1002/hlca.19960790219
(1996)
