Design and synthesis of bisubstrate analogues for 3-hydroxy-3-methyl-glutaryl coenzyme A reductase

Article abstract of DOI:10.1016/0960-894X(96)00077-7

The coupling of metalated pyridine derivatives with a chiral Weinreb amide derived from gluconolactone followed by stereoselective reduction of the resulting ketone are the key steps of the synthesis of bisubstrates analogues of the HMGCoA reduction by HMGR.