Catalytic asymmetric intramolecular cyclopropanation of enol silyl ether. Synthesis of the phorbol CD-ring skeleton

DOI: 10.1016/0040-4039(96)00315-2

Source and publish data:

Tetrahedron Letters p. 2449 - 2452 (1996)

Update date:2022-09-26

Topics:

Authors:

Tokunoh, Ryosuke

Tomiyama, Hiroshi

Sodeoka, Mikiko

Shibasaki, Masakatsu

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Article abstract of DOI:10.1016/0040-4039(96)00315-2

The optically active phorbol CD-ring skeleton was constructed using the catalytic asymmetric intramolecular cyclopropanation of enol silyl ether as a key step. Up to 92% ee was achieved using a newly modified bisoxazoline ligand.

Full text of DOI:10.1016/0040-4039(96)00315-2

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