Catalytic asymmetric intramolecular cyclopropanation of enol silyl ether. Synthesis of the phorbol CD-ring skeleton

Article abstract of DOI:10.1016/0040-4039(96)00315-2

The optically active phorbol CD-ring skeleton was constructed using the catalytic asymmetric intramolecular cyclopropanation of enol silyl ether as a key step. Up to 92% ee was achieved using a newly modified bisoxazoline ligand.