An efficient synthesis of cis-3-hydroxy-4-phenyl-β-lactams: Precursor for taxol side chain

Article abstract of DOI:10.1016/0040-4020(96)00200-1

Chiral ketone precursors derived from naturally occurring (+)-3-carene have been used for the synthesis of β-lactams via the Staudinger reaction. The major diastereomer 5a was separated by crystallization and converted in very good yield into (3R,4S)-3-hy