Synthetic Communications p. 1605 - 1611 (1996)
Update date:2022-09-26
Topics:
Micouin, Laurent
Quirion, Jean-Charles
Husson, Henri-Philippe
Bicyclic lactams 8 have been prepared in enantiomerically pure form from the corresponding amino esters 5 and glutaric anhydride. The key step is the reduction of imides 7 in methanol. Selective reduction of 8 furnished N-substituted lactams 9.
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