Improvement of the synthesis of chiral non-racemic bicyclic lactams in the piperidin-2-ones series

Article abstract of DOI:10.1080/00397919608003529

Bicyclic lactams 8 have been prepared in enantiomerically pure form from the corresponding amino esters 5 and glutaric anhydride. The key step is the reduction of imides 7 in methanol. Selective reduction of 8 furnished N-substituted lactams 9.

Full text of DOI:10.1080/00397919608003529

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Synthetic Communications: An
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Improvement of the Synthesis
of Chiral Non-Racemic Bicyclic
Lactams in the Piperidin-2-
ones Series
Laurent Micouin a , Jean-Charles Quirion a & Henri-
Philippe Husson a
a Laboratoire de Chimie Thérapeutique associé au
C.N.R.S. Faculté des Sciences Pharmaceutiques et
Biologiques Université René , Descartes, 4, Avenue
de l'Observatoire, 75270, Paris Cedex 06, France
Published online: 15 Aug 2006.
To cite this article: Laurent Micouin , Jean-Charles Quirion & Henri-Philippe Husson
(1996) Improvement of the Synthesis of Chiral Non-Racemic Bicyclic Lactams in
the Piperidin-2-ones Series, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 26:8, 1605-1611, DOI:
10.1080/00397919608003529
To link to this article: http://dx.doi.org/10.1080/00397919608003529
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