Improvement of the synthesis of chiral non-racemic bicyclic lactams in the piperidin-2-ones series

Article abstract of DOI:10.1080/00397919608003529

Bicyclic lactams 8 have been prepared in enantiomerically pure form from the corresponding amino esters 5 and glutaric anhydride. The key step is the reduction of imides 7 in methanol. Selective reduction of 8 furnished N-substituted lactams 9.