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Na+-glucose cotransporter inhibitors as antidiabetics. I. Synthesis and pharmacological properties of 4'-dehydroxyphlorizin derivatives based on a new concept

DOI: 10.1248/cpb.44.1174

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1174 - 1180 (1996)

Update date:2022-09-26

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Authors:

Tsujihara, KenjiTsujihara, Kenji

Hongu, MitsuyaHongu, Mitsuya

Saito, KunioSaito, Kunio

Inamasu, MasanoriInamasu, Masanori

Arakawa, KenjiArakawa, Kenji

Oku, AkiraOku, Akira

Matsumoto, MamoruMatsumoto, Mamoru

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Article abstract of DOI:10.1248/cpb.44.1174

Based on our new concept that inhibitors of the Na+-glucose cotransporter (SGLT) would be useful as antidiabetics, 4'-dehydroxyphlorizin derivatives 1a-f were designed, synthesized, and examined for various pharmacological properties related to

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Full text of DOI:10.1248/cpb.44.1174

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Product name:(E)-1-[2-Hydroxy-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-3-(4-methoxy-phenyl)-propenone

Cas No:176706-79-9

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