
Tetrahedron Asymmetry p. 1101 - 1104 (1996)
Update date:2022-08-03
Topics:
Ramacciotti, Alessio
Fiaschi, Rita
Napolitano, Elio
In a process which appears to be general for the enantioselective synthesis of oxysubstituted 1,2-diarylethanols, a 4-methoxy-3-silyloxyphenyllithium, obtained by bromine-lithium exchange from the corresponding aryl bromide and t-butyllithium, added selectively at the b-carbon of (S)-2,3,4-trimethoxyphenyloxirane, elaborated from the corresponding styrene via Sharpless asymmetric dihydroxylation, to afford an adduct from which natural (-)-combretastatin was obtained by desilylation.
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Doi:10.1016/0040-4039(96)00537-0
(1996)Doi:10.1007/BF01172574
()Doi:10.1039/c8cc00888d
(2018)Doi:10.1021/op050202l
(2006)Doi:10.1016/j.tetlet.2007.05.158
(2007)Doi:10.1016/0040-4020(96)00255-4
(1996)