Two syntheses of 2S-[2-2H]-kynurenine

DOI: 10.1016/0960-894X(96)00128-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 875 - 878 (1996)

Update date:2022-08-04

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Authors:

Ross, Fiona C.

Botting, Nigel P.

Leeson, Paul D.

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Article abstract of DOI:10.1016/0960-894X(96)00128-X

The synthesis of 2S-[2-²H]-kynurenine is described using two different routes. Diacetylation/racemisation of racemic kynurenine in deuterium oxide followed by acylase catalysed resolution is the most direct route. The alternative is to prepare 2S-[2-²H]-tryptophan by a similar procedure and then convert this through to 2S-[2-²H]-kynurenine via ozonolysis.

Full text of DOI:10.1016/0960-894X(96)00128-X

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