Bioorganic and Medicinal Chemistry Letters p. 875 - 878 (1996)
Update date:2022-08-04
Topics:
Ross, Fiona C.
Botting, Nigel P.
Leeson, Paul D.
The synthesis of 2S-[2-2H]-kynurenine is described using two different routes. Diacetylation/racemisation of racemic kynurenine in deuterium oxide followed by acylase catalysed resolution is the most direct route. The alternative is to prepare 2S-[2-2H]-tryptophan by a similar procedure and then convert this through to 2S-[2-2H]-kynurenine via ozonolysis.
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