A direct approach to the synthesis of famciclovir and penciclovir

Article abstract of DOI:10.1080/07328319608002029

Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1- tricarboxylate followed by decarbethoxylation/transsesterification of the unpurified product was the key sequence in sythesising both the anti- herpesvirus agent penciclovir and its form famciclovir in three isolated steps.

Full text of DOI:10.1080/07328319608002029

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Nucleosides and Nucleotides
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A Direct Approach to the Synthesis of
Famciclovir and Penciclovir
Bernadette M. Choudary a , Graham R. Geen a , Peter M. Kincey
a , Martin J. Parratt a , J. Robert b , M. Dales b , Graham P.
Johnson b , Steven O'Donnell b , David W. Tudor b & Neil Woods b
a SmithKline Beecham Pharmaceuticals, New Frontiers Science
Park, Third Avenue, Harlow, Essex, CM19 5AW, U. K.
b SmithKline Beecham Pharmaceuticals, Clarendon Road,
Worthing, West Sussex, BN14 8QH, U. K.
Published online: 15 Aug 2006.
To cite this article: Bernadette M. Choudary , Graham R. Geen , Peter M. Kincey , Martin J.
Parratt , J. Robert , M. Dales , Graham P. Johnson , Steven O'Donnell , David W. Tudor & Neil
Woods (1996): A Direct Approach to the Synthesis of Famciclovir and Penciclovir, Nucleosides and
Nucleotides, 15:5, 981-994
To link to this article: http://dx.doi.org/10.1080/07328319608002029
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