Nucleosides and Nucleotides p. 981 - 994 (1996)
Update date:2022-08-03
Topics: Synthesis Catalyst Chemical reactions Reactants Purification Reaction Conditions Product Analytical Techniques Experimental Setup Direct approach Famciclovir Penciclovir
Choudary, Bernadette M.
Geen, Graham R.
Kincey, Peter M.
Parratt, Martin J.
Dales, J. Robert M.
Johnson, Graham P.
O'Donnell, Steven
Tudor, David W.
Woods, Neil
Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1- tricarboxylate followed by decarbethoxylation/transsesterification of the unpurified product was the key sequence in sythesising both the anti- herpesvirus agent penciclovir and its form famciclovir in three isolated steps.
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Doi:10.1021/jm950881y
(1996)Doi:10.1021/ja960001k
(1996)Doi:10.1021/jo971698a
(1998)Doi:10.1021/jm970498o
(1998)Doi:10.1016/0040-4039(96)00834-9
(1996)Doi:10.1021/jo800185v
(2008)