Bioorganic and Medicinal Chemistry Letters p. 1061 - 1066 (1996)
Update date:2022-08-03
Topics:
Bunker, Amy M.
Edmunds, Jeremy J.
Berryman, Kent A.
Walker, Donnelle M.
Flynn, Michael A.
Welch, Kathy M.
Doherty, Annette M.
Endothelin-1 is a potent vasoconstrictor that is thought to be involved in many human disease states. We have developed a series of indole non-peptide endothelin antagonists including PD 159110 (31), and ET(A) selective antagonist, and PD 159020 (37), a non-selective ET(A)/ET(B) antagonist. The discovery, synthesis, and structure-activity relationships of this series of compounds are described.
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Doi:10.1016/0040-4020(96)00323-7
(1996)Doi:10.1002/jhet.5570330208
(1996)Doi:10.1111/j.1432-1033.1970.tb00823.x
(1970)Doi:10.1016/0040-4039(95)02418-2
(1996)Doi:10.1039/p19960001125
(1996)Doi:10.1039/c5sc03463a
(2016)
