Bioorganic and Medicinal Chemistry Letters p. 3369 - 3374 (1999)
Update date:2022-07-31
Topics:
Bourrain, Sylvie
Neduvelil, Joseph G.
Beer, Margaret S.
Stanton, Josephine A.
Showell, Graham A.
Macleod, Angus M.
A series of 4-hydroxy-l-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl] piperidines was investigated as potential selective h5-HT(1D) agonists for the treatment of migraine. The 4-[(N-benzyl-N-methyl)amino]methyl analog 12a was found to be a full agonist
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