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4-hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines: Selective h5-HT(1D) agonists for the treatment of migraine

DOI: 10.1016/S0960-894X(99)00614-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3369 - 3374 (1999)

Update date:2022-07-31

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Authors:

Bourrain, SylvieBourrain, Sylvie

Neduvelil, Joseph G.Neduvelil, Joseph G.

Beer, Margaret S.Beer, Margaret S.

Stanton, Josephine A.Stanton, Josephine A.

Showell, Graham A.Showell, Graham A.

Macleod, Angus M.Macleod, Angus M.

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Article abstract of DOI:10.1016/S0960-894X(99)00614-9

A series of 4-hydroxy-l-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl] piperidines was investigated as potential selective h5-HT(1D) agonists for the treatment of migraine. The 4-[(N-benzyl-N-methyl)amino]methyl analog 12a was found to be a full agonist

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Full text of DOI:10.1016/S0960-894X(99)00614-9

Products guided by the article

Product name:4-hydroxy-4-(2-methylphenylmethyl)aminomethyl-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine

Cas No:177946-91-7

177946-91-7

R&D Labs maybe for 177946-91-7

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