Tetrahedron Letters p. 3467 - 3470 (1996)
Update date:2022-08-04
Topics: Multidrug resistance Cyclic Experimental Synthetic study Depsipeptide
Ohmori, Ken
Okuno, Toshiaki
Nishiyama, Shigeru
Yamamura, Shosuke
Hapalosin possessing a multidrug resistance reversing activity, has been synthesized from the corresponding hydroxy acids and γ-amino acids. The stereochemistry of the natural product and related derivatives is discussed.
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