Lewis-acid promoted addition of 2-trimethylsilyloxyfuran to nitrones: Synthesis and absolute configuration of tetrahydro-2-benzyl-3-(1-benzyloxyethyl)-furo[2,3-d]isoxazol-5(2H)ones

DOI: 10.1016/0957-4166(96)00110-3

Source and publish data:

Tetrahedron Asymmetry p. 1059 - 1068 (1996)

Update date:2022-08-02

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Authors:

Castellari, Carlo

Lombardo, Marco

Pietropaolo, Graziano

Trombini, Claudio

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Article abstract of DOI:10.1016/0957-4166(96)00110-3

A straightforward synthesis of tetrahydro-2-benzyl-3-(1-benzyloxyethyl)-furo[2,3-d]isoxazol-5(2H)ones is reported, based on the Lewis acid-catalysed addition of 2-trimethylsilyloxyfuran to the N-benzyl nitrone of (S)-lactaldehyde.

Full text of DOI:10.1016/0957-4166(96)00110-3

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Product name:(3R,3aR,6aR)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

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