Synthesis of glycopolymers containing GM3-saccharide

Article abstract of DOI:10.1016/0040-4039(96)00584-9

GM₃-trisaccharide [Neu5Acα-)2 → 3)-Galβ-(1 → 4)-Glcβ-(1 → OR] was synthesized using our 'active-latent' thioglycosylation strategy. The trisaccharide was prepared with a p-acrylamidophenyl aglycon for copolymerization with acrylamide. The resulting water-soluble sialyl α-(2 → 3)-lactoside copolyacrylamide with different carbohydrate incorporation was shown to possess antigenic properties.