A general and convenient synthesis of novel phosphotyrosine mimetics

Article abstract of DOI:10.1016/0040-4039(96)00666-1

A simple and general procedure for preparation of various phosphotyrosine mimetics from the corresponding phenolic precursors is described. In situ silylation of phenol acids followed by treatment with Et₃N/CBr₄/HP(O)(OEt)₂ provides diethyl phosphate intermediates (36-96%), which can be cleanly deprotected in quantitative yields upon treatment with BSTFA/TMSI to afford novel phosphotyrosine mimetics.