A general and convenient synthesis of novel phosphotyrosine mimetics

DOI: 10.1016/0040-4039(96)00666-1

Source and publish data:

Tetrahedron Letters p. 3635 - 3638 (1996)

Update date:2022-08-04

Topics:

Authors:

Szardenings, Anna Katrin

Gordeev, Mikhail F.

Patel, Dinesh V.

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Article abstract of DOI:10.1016/0040-4039(96)00666-1

A simple and general procedure for preparation of various phosphotyrosine mimetics from the corresponding phenolic precursors is described. In situ silylation of phenol acids followed by treatment with Et₃N/CBr₄/HP(O)(OEt)₂ provides diethyl phosphate intermediates (36-96%), which can be cleanly deprotected in quantitative yields upon treatment with BSTFA/TMSI to afford novel phosphotyrosine mimetics.

Full text of DOI:10.1016/0040-4039(96)00666-1

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