Chemical and Pharmaceutical Bulletin p. 1256 - 1263 (2000)
Update date:2022-09-26
Topics:
Sakagami, Masahiro
Horie, Kazutoshi
Nakamoto, Kazutaka
Kawaguchi, Takayuki
Hamana, Hiroshi
Sialyl Lewis X (SLe(x)) is well known as a ligand of the cell adhesion molecule E-selectin which is specifically expressed at inflammatory lesion sites. We have synthesized several SLe(x)-polysaccharide conjugates and examined their potential for drug delivery to inflammatory lesions. The AUC (area under the blood concentration-time curve) 0 - 24 h of SLe(x)-CMCht (1), SLe(x)-CMPul (2) and SLe(x)-DSH (3) at the inflammatory lesion was about 60-, 300-, and 30-fold higher than that of the monovalent SLe(x) (7), respectively. Moreover, 1 showed 2-fold higher accumulation in the inflammatory lesion than SLN-CMCht (4), and 2 showed 2.5-fold higher accumulation than SLN-CMPul (5).
View MoreContact:+86-22-26358246
Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
website:http://www.simagchem.com
Contact:+86-592-2680277
Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
shanghai hekang chemical co.ltd
Contact:021-54173790
Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
zhuzhou zhongle chemical co. ltd.
Contact:+86-0731 28228409
Address:Zhuzhou, Hunan, China
Contact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Doi:10.1016/S1381-1169(97)00059-9
(1997)Doi:10.1021/jo9609900
(1996)Doi:10.1021/ja01468a040
(1961)Doi:10.1021/ja962086v
(1996)Doi:10.1016/S0022-328X(97)00075-2
(1997)Doi:10.1007/BF00474882
()
