Chemical and Pharmaceutical Bulletin p. 1256 - 1263 (2000)
Update date:2022-09-26
Topics:
Sakagami, Masahiro
Horie, Kazutoshi
Nakamoto, Kazutaka
Kawaguchi, Takayuki
Hamana, Hiroshi
Sialyl Lewis X (SLe(x)) is well known as a ligand of the cell adhesion molecule E-selectin which is specifically expressed at inflammatory lesion sites. We have synthesized several SLe(x)-polysaccharide conjugates and examined their potential for drug delivery to inflammatory lesions. The AUC (area under the blood concentration-time curve) 0 - 24 h of SLe(x)-CMCht (1), SLe(x)-CMPul (2) and SLe(x)-DSH (3) at the inflammatory lesion was about 60-, 300-, and 30-fold higher than that of the monovalent SLe(x) (7), respectively. Moreover, 1 showed 2-fold higher accumulation in the inflammatory lesion than SLN-CMCht (4), and 2 showed 2.5-fold higher accumulation than SLN-CMPul (5).
View MoreContact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
Wuhan Benjamin Pharmaceutical Chemical Co.,Ltd
Contact:86-27-52341789
Address:Room 1518 B suite, optical valley time square, No 111 Guanshan Road, Hongshan District,Wuhan,Hubei Province,China.
Shenzhen Hongyuan Import & Export Co., Ltd.
Contact:0755-26407171
Address:Shenzhen Hongyuan Chemical New Materials Technology Co., Ltd.
Suzhou Tianma Specialty Chemicals Co.,Ltd
Contact:+86-512-68090577
Address:#199, Huayuan Rd, Mudu, Suzhou, Jiangsu, CHINA
Hangzhou GreenCo Science & Technology Co., Ltd.
Contact:86-571-88257303
Address:1713 Room,Jingui Building,Gudun Road,Xihu District,Hangzhou,China
Doi:10.1016/S1381-1169(97)00059-9
(1997)Doi:10.1021/jo9609900
(1996)Doi:10.1021/ja01468a040
(1961)Doi:10.1021/ja962086v
(1996)Doi:10.1016/S0022-328X(97)00075-2
(1997)Doi:10.1007/BF00474882
()
