Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin

Article abstract of DOI:10.1016/0040-4039(96)00600-4

The preparation of three analogues of the putative diketide biosynthetic precursor (2) and eight analogues of the putative triketide biosynthetic precursor (3) of the acyl tetronic acid ionophore tetronasin, as N-acetylcysteamine thioesters (4), (5), (6), (12), (13), (14), (15), (22), (23), (24) and (25) is described. Five examples are ¹⁹F-labelled; a new, enantiospecific method for the creation of a fluorinated quarternary α-centre is presented.