Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor

DOI: 10.1021/jm0503493

Source and publish data:

Journal of Medicinal Chemistry p. 864 - 871 (2006)

Update date:2022-07-29

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Authors:

Buchstaller, Hans-Peter

Siebert, Carsten D.

Steinmetz, Ralf

Frank, Ina

Berger, Michael L.

Gottschlich, Rudolf

Leibrock, Joachim

Krug, Michael

Steinhilber, Dieter

Noe, Christian R.

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Article abstract of DOI:10.1021/jm0503493

The standard glycine site antagonist of the N-methyl-D-aspartate (NMDA) receptor, 3-phenyl-4-hydroxyquinolin-2(1H)-one (21), was used as a template for bioisostere benzene/thiophene exchange. Phenylacetylation of aminothiophene carboxylic acid methyl este

Full text of DOI:10.1021/jm0503493

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