Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2- (1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity

Article abstract of DOI:10.1021/jm9600813

A series of aryl-monosubstituted arylacetamides (4-9) and arylethylenediamine (10-18) compounds were synthesized based on the structure of the high-affinity sigma ligand N-[2(3,4-dichlorophenyl)ethyl]-N-methyl-2- (1-pyrrolidinyl)ethylamine (2). These comp