Relationship between chemical structure and antileishmanial effect of sinefungine analogues

Article abstract of DOI:10.1080/07328319608007381

The synthesis of various analogues of sinefungin (1), having structures 2- 5, has been developed by means of an original approach which uses radical chemistry. The study of their biological activities revealed that for the antileishmanial effect of sinefungin, the presence of the amino group at C- 6' in the (S)-configuration and the presence of the carboxyl group at C-9' are necessary.

Full text of DOI:10.1080/07328319608007381

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Nucleosides and Nucleotides
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Relationship Between Chemical
Structure and Antileishmanial Effect
of Sinefungine Analogues
P. Blanchard a , M. S. El Kortbi a , J. -L. Fourrey a , F. Lawrence a
& M. Robert-Gero a
a Institut de Chimie des Substances Naturelles, C.N.R.S. , 91198,
Gif-sur-Yvette, Cedex, France
Published online: 19 Aug 2006.
To cite this article: P. Blanchard , M. S. El Kortbi , J. -L. Fourrey , F. Lawrence & M. Robert-
Gero (1996) Relationship Between Chemical Structure and Antileishmanial Effect of Sinefungine
Analogues, Nucleosides and Nucleotides, 15:6, 1121-1135, DOI: 10.1080/07328319608007381
To link to this article: http://dx.doi.org/10.1080/07328319608007381
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