Combined glycomimetic and multivalent strategies for the design of potent selectin antagonists

DOI: 10.1016/0960-894X(96)00240-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1399 - 1402 (1996)

Update date:2022-08-04

Topics:

Authors:

Roy, Rene

Park, William K. C.

Srivastava, Om P.

Foxall, Carrol

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00240-5

Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for copolymerization with acrylamide has been achieved. The resulting water- soluble copolyacrylamide showed inhibition of binding of both L- and E- selectins in the μMolar range.

Full text of DOI:10.1016/0960-894X(96)00240-5

Products guided by the article

Product name:9-[(2R,3R,4S,5R,6R)-3-Benzyloxy-6-benzyloxymethyl-5-hydroxy-4-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid methyl ester

Cas No:180074-72-0

R&D Labs maybe for 180074-72-0

Eastar Chemical Corporation

website:http://www.eastarchem.com/

Contact:1-800-898-2436

Address:1215 K Street, STE 1700
Huangshan Honghui Pharm Technology Co., Ltd.(expird)

website:http://www.honghuichem.com

Contact:18855958372

Address:Qingshan Wan No.1,Nanyuan Kou,SheXian Huangshan City,Anhui Province
Suzhou Tianma Specialty Chemicals Co.,Ltd

Contact:+86-512-68090577

Address:#199, Huayuan Rd, Mudu, Suzhou, Jiangsu, CHINA
Anhui Jiatiansen Agrochemical Co.,Ltd

Contact:15366811918

Address:chemical industrial park,xiangyu town,dongzhi county,anhui,china
Shanghai Rainbow Chemistry Co., Ltd.

Contact:+86-21-64968086-5815/5812

Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China

Relevant to this article

Reaction of metallated tert-butyl(phenyl)phosphane oxide with electrophiles as a route to functionalized tertiary phosphane oxides: Alkylation reactions

Doi:10.1002/1099-0690(200009)2000:18<3205::AID-EJOC3205>3.0.CO;2-D
(2000)
Synthesis and characterization of chiral nitronic esters via O-alkylation of (4S*,5R)-(+)-4-(1′-nitro-1′-carbethoxymethyl)-5-[(1R)- menthyloxy]-3,4-dihydro-2(5H)-furanone with alkyl halides

Doi:10.1021/jo951902z
(1996)
Doi:10.1021/j150558a005
(1957)
Doi:10.1021/jm00308a023
(1968)
Chemo-selective oxidation of hydroxybenzyl alcohols with IBX in the presence of hemicucurbit[6]uril

Doi:10.1039/c3nj00660c
(2013)
Synthesis of some novel 2-phenylpyridazino[4,5-b][1,5]thiazepines

Doi:10.1002/jhet.5570330309
(1996)

Article Doi