Combined glycomimetic and multivalent strategies for the design of potent selectin antagonists

DOI: 10.1016/0960-894X(96)00240-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1399 - 1402 (1996)

Update date:2022-08-04

Topics:

Authors:

Roy, Rene

Park, William K. C.

Srivastava, Om P.

Foxall, Carrol

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Article abstract of DOI:10.1016/0960-894X(96)00240-5

Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for copolymerization with acrylamide has been achieved. The resulting water- soluble copolyacrylamide showed inhibition of binding of both L- and E- selectins in the μMolar range.

Full text of DOI:10.1016/0960-894X(96)00240-5

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