Combined glycomimetic and multivalent strategies for the design of potent selectin antagonists

DOI: 10.1016/0960-894X(96)00240-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1399 - 1402 (1996)

Update date:2022-08-04

Topics:

Authors:

Roy, Rene

Park, William K. C.

Srivastava, Om P.

Foxall, Carrol

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00240-5

Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for copolymerization with acrylamide has been achieved. The resulting water- soluble copolyacrylamide showed inhibition of binding of both L- and E- selectins in the μMolar range.

Full text of DOI:10.1016/0960-894X(96)00240-5

Products guided by the article

Product name:9-[(2R,3R,4S,5R,6R)-3-Benzyloxy-6-benzyloxymethyl-5-hydroxy-4-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid methyl ester

Cas No:180074-72-0

R&D Labs maybe for 180074-72-0

LIDE PHARMACEUTICALS LIMITED

website:http://www.lidepharma.com

Contact:+86-25-58409506

Address:Chungking Express Nos.36 Nathan Road，Kowloon, HK
xujianqiang

Contact:86-21-57725962

Address:shanghai
Shanghai Mio Chemical Co., Ltd

Contact:0086 21- 64401188-622

Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China
suzhou chukai pharmateach co,.ltd

Contact:86-512-88812511

Address:Building 3, Wujiang Scientific Innovation Park, 2358 Changan Rd, Wujiang 215200, Jiangsu Province, P. R. China
Jitat Company Ltd

Contact:852-27701081

Address:Room 2509, New Tech Plaza, 34 Tai Yau St., San Po Kong, HK

Relevant to this article

Reaction of metallated tert-butyl(phenyl)phosphane oxide with electrophiles as a route to functionalized tertiary phosphane oxides: Alkylation reactions

Doi:10.1002/1099-0690(200009)2000:18<3205::AID-EJOC3205>3.0.CO;2-D
(2000)
Synthesis and characterization of chiral nitronic esters via O-alkylation of (4S*,5R)-(+)-4-(1′-nitro-1′-carbethoxymethyl)-5-[(1R)- menthyloxy]-3,4-dihydro-2(5H)-furanone with alkyl halides

Doi:10.1021/jo951902z
(1996)
Doi:10.1021/j150558a005
(1957)
Doi:10.1021/jm00308a023
(1968)
Chemo-selective oxidation of hydroxybenzyl alcohols with IBX in the presence of hemicucurbit[6]uril

Doi:10.1039/c3nj00660c
(2013)
Synthesis of some novel 2-phenylpyridazino[4,5-b][1,5]thiazepines

Doi:10.1002/jhet.5570330309
(1996)

Article Doi