Asymmetric synthesis; XXXVII: Synthesis of 2,6-disubstituted piperazines from chiral non-racemic lactams

Article abstract of DOI:10.1055/s-1996-4299

General and convenient syntheses of optically active 2,6-disubstituted piperazines are described. The method is based on diastereoselective alkylation of lactam 8 derived from (R)-(-)-phenylglycinol followed by a regio- and diastereoselective functionalisation of carbamates 10c and 10d. This procedure allowed the preparation of new α-amino acids 15 and 16.