Synthesis of enantiomerically pure (1R,2S)- and (1S,2R)-2-amino-1,2-bis(pentafluorophenyl)ethanols

Article abstract of DOI:10.1016/0957-4166(96)00221-2

Enantiomerically pure (1R,2S)- and (1S,2R)-2-amino-1,2-bis(pentafluorophenyl)-ethanols 1a and 1b have been prepared from (±)-2-(t-butyldimethylsiloxy)-2-(pentafluorophenyl)acetonitrile in three steps involving resolution of (±)-1 by salt formation with D-