Bioorganic and Medicinal Chemistry p. 1077 - 1088 (1996)
Update date:2022-08-02
Topics:
Parry, Ronald J.
Burns, Mark R.
Skae, Phillip N.
Hoyt, Jeffrey C.
Pal, Biman
The synthesis of cyclopentyl and cyclopentenyl analogues of the α- anomer of D-ribose-5-phosphate from D-ribonolactone and D-ribose is described. These analogues, which have the same absolute configuration as D- ribose-5-phosphate, were incubated with PRPP synthetases in an attempt to prepare the corresponding carbocyclic PRPP analogues. The carbocyclic ribose- 5-phosphate analogues were found to be inhibitors, rather than substrates, for 5-phosphoribosyl α-1-pyrophosphate synthetases of both bacterial and human origin. The inhibitory behavior of the analogues is described.
View MoreSHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD
website:http://www.jinjingroup.com
Contact:4009982989
Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China
website:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
Tianjin Ji Ping Jia Chemical Co., Ltd.
Contact:18622448868
Address:tianjin
Sichuan WeiKeqi Biological Technology Co., Ltd.
Contact:86-028-81700200
Address:sichuan Chengdu Qingjiang Zhonglu 63号
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.
Contact:+86-25-83767696
Address:14-7 Zhongshan Lu Guluo District, Nanjing
Doi:10.1016/S0040-4039(00)98062-6
(1990)Doi:10.1039/c0jm04274a
(2011)Doi:10.1007/BF00473959
(1990)Doi:10.1016/j.tetlet.2011.04.122
(2011)Doi:10.1016/0040-4039(91)80035-5
(1991)Doi:10.1002/anie.201404154
(2014)