Versatile synthesis of L-α-amino acids stereospecifically labelled on the β-carbon atom

Article abstract of DOI:10.1016/0040-4020(96)00521-2

Inversion of the stereochemistry at the α-centre of stereospecifically labelled samples of (2S)-isoserine (7) using a sequence involving an intramolecular substitution reaction has allowed synthesis of the stereospecifically labelled aziridines (19) to be completed. These are synthons for a very versatile preparation of L-amino acids which are stereospecifically labelled at the β-carbon atom.