Catalytic asymmetric synthesis of protected α-hydroxy aldehydes and related 1,2-difunctional chiral building blocks. An enantioselective synthesis of (-)-exo- and (-)-endo-brevicomin

Article abstract of DOI:10.1016/S0957-4166(97)00036-0

Chiral allylic alcohols which were prepared by the addition of functionalized dialkylzincs to α,β-unsaturated aldehydes in good to excellent enantioselectivity, were converted to protected α-hydroxy aldehydes and 1,2-amino alcohols without loss of enantio