Enzymatic hydrolyses of acetoxy- and phenethylbenzoates by Candida cylindracea lipase

Article abstract of DOI:10.1016/0040-4020(96)00519-4

The lipase from Candida cylindracea (CCL) deacctyles rapidly and selective all three regioisomer methyl acctoxybenzoates. In the enzymatic hydrolyses of analogous aryl acctoxybenzoates, the difference of reactivity between the acetoxy and benzoloxy funcionalities is reduced and a aspirin- like prodrugs. The degree of enantioselectivity of the enzymatic hydrolysis of phenethylbenzoates is related to the position of the stereogenic center.