Bioorganic and Medicinal Chemistry Letters p. 1387 - 1392 (1996)
Update date:2022-08-03
Topics:
Dubois, Eric P.
Robbins, John B.
Pozsgay, Vince
Di- to penta-saccharide fragments (2-5) of Polysaccharide II (PS-II) of Mycobacterium tuberculosis were synthesized in spacer-linked form in a stepwise fashion using a new glycosyl donor featuring a trans-fused isopropylidene diol-protecting group. Covalent attachment of the oligosaccharides to proteins provides semi-synthetic antigens and immunogens which are being used to probe the role of PS-II as a possible mycobacterial antigen.
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