Butyrophenone analogues in the carbazole series: Synthesis and determination of affinities at D2 and 5-HT(2A) receptors

DOI: 10.1016/S0960-894X(98)00639-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3571 - 3576 (1998)

Update date:2022-07-30

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Authors:

Masaguer, Christian F.

Formoso, Emilio

Ravina, Enrique

Tristan, Helena

Loza, M. Isabel

Rivas, Emilia

Fontenla, Jose Angel

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Article abstract of DOI:10.1016/S0960-894X(98)00639-8

We describe a practical and efficient route for synthesis of 2- aminomethyl-1,2,3,9-tetrahydro-4H-carbazol-4-ones using an effective Fisher indole methodology. The most active compounds, 4b (QF 2003B) and 4c (QF 2004B), with pKi (5-HT(2A)/D₂) r

Full text of DOI:10.1016/S0960-894X(98)00639-8

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