Total synthesis of cyclostellettamine C, a bispyridinium macrocyclic alkaloid having muscarinic acetylcholine receptor antagonistic activity

DOI: 10.1016/0040-4020(96)00628-X

Source and publish data:

Tetrahedron p. 10849 - 10860 (1996)

Update date:2022-08-02

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Authors:

Anan, Hideki

Seki, Norio

Noshiro, Osamu

Honda, Kazuo

Yasumuro, Kenichi

Ozasa, Teruaki

Fusetani, Nobuhiro

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Article abstract of DOI:10.1016/0040-4020(96)00628-X

Cyclostellettamine C (1), a bispyridinium macrocyclic compound having muscarinic acetylcholine receptor antagonistic activity, was synthesized by the stepwise ring closure method via 3-(13-hydroxytridecyl)-1-[13-(3-pyridyl)tridecyl]pyridinium trifluoromethanesulfonate (21). Through this study, the structure of naturally originating 1 was synthetically and biologically confirmed.

Full text of DOI:10.1016/0040-4020(96)00628-X

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