Total synthesis of cyclostellettamine C, a bispyridinium macrocyclic alkaloid having muscarinic acetylcholine receptor antagonistic activity

Article abstract of DOI:10.1016/0040-4020(96)00628-X

Cyclostellettamine C (1), a bispyridinium macrocyclic compound having muscarinic acetylcholine receptor antagonistic activity, was synthesized by the stepwise ring closure method via 3-(13-hydroxytridecyl)-1-[13-(3-pyridyl)tridecyl]pyridinium trifluoromethanesulfonate (21). Through this study, the structure of naturally originating 1 was synthetically and biologically confirmed.