Convenient syntheses of 6-methylpurine and related nucleosides

Article abstract of DOI:10.1080/15257770008035035

Efficient methods for the synthesis of 6-methylpurine (3), 9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methylpurine (8), and 6-methyl-9-β-D-ribofuranosylpurine (5) are described. Methodology involving the (Ph₃P)₄Pd catalyzed cross-coupling reaction of CH₃ZnBr with several different 6-chloropurine derivatives is described in high yield. This methodology now provides a facile and high-yielding synthesis of 8, which is needed in significant amounts for studies in cancer gene therapy.

Full text of DOI:10.1080/15257770008035035

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Nucleosides, Nucleotides and Nucleic
Acids
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Convenient Syntheses of 6-Methylpurine
and Related Nucleosides
Abdalla E. A. Hassan a , Reham A. I. Abou-elkair a , John A.
Montgomery a & John A. Secrist III a
a Drug Discovery Division, Organic Chemistry Department, Southern
Research Institute, P. O. Box 55305, Birmingham, AL, 35255-5305,
U.S.A.
Published online: 05 Nov 2010.
To cite this article: Abdalla E. A. Hassan , Reham A. I. Abou-elkair , John A. Montgomery & John
A. Secrist III (2000) Convenient Syntheses of 6-Methylpurine and Related Nucleosides, Nucleosides,
Nucleotides and Nucleic Acids, 19:7, 1123-1134, DOI: 10.1080/15257770008035035
To link to this article: http://dx.doi.org/10.1080/15257770008035035
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