Synthesis of [3.3.0] bicyclic isoxazolidinyl nucleosides

DOI: 10.1016/S0960-894X(96)00262-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1475 - 1478 (1996)

Update date:2022-08-03

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Authors:

Xiang, Yuejun

Schinazi, Raymond F.

Zhao, Kang

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Article abstract of DOI:10.1016/S0960-894X(96)00262-4

The isoxazolidine derivative 6, prepared from an intermolecular 1,3- dipolar cycloaddition of the (5S)-unsaturated lactone 5 and N-methylnitrone, was effectively used for the synthesis of [3.3.0] bicyclic isoxazolidinyl cytidine 4a and thymidine 4b.

Full text of DOI:10.1016/S0960-894X(96)00262-4

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