Synthesis of optically active β,γ-alkynylglycine derivatives

Article abstract of DOI:10.1016/0040-4020(96)00630-8

Full results on the first synthesis of optically active β,γ-alkynylglycine derivatives from naturally occurring L-serine are described. The methodology uses L-serinal as a key intermediate and allows great versatility in the introduction of N-protective groups and of alkyne substitution. The N-Boc protected β,γ-alkynylglycine derivatives described have ee greater than 90%.