Bioorganic and Medicinal Chemistry Letters p. 1573 - 1576 (1996)
Update date:2022-08-04
Topics:
Aoyagi, Mitsutoshi
Ueno, Yoshihito
Ono, Akira
Matsuda, Akira
1-(2-Bromo-2-deoxy-β-D-ribofuranosyl)adenine (1) and 1-(2-bromo-2- deoxy-β-D-arabinofuranosyl)adenine (2) were incorporated into DNA pentadecamers. The oligonucleotides containing 1 destabilized DNA/DNA and DNA/RNA duplex formation. However, the oligonucleotides containing 2 slightly stabilized DNA/DNA duplex formation, although they decreased the stability of DNA/RNA duplexes. Furthermore, the oligonucleotide containing 2 was more resistant to snake venom phosphodiesterase than an unmodified oligonucleotide (dA)15 and the oligonucleotide containing 1.
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Doi:10.1021/jo960891m
(1996)Doi:10.1021/jo960758u
(1996)Doi:10.1080/00397919608003784
(1996)Doi:10.1016/0022-328X(96)06207-9
(1996)Doi:10.1055/s-1998-2076
(1998)Doi:10.1021/ic960555o
(1996)