Organic Process Research and Development p. 1835 - 1845 (2018)
Update date:2022-08-03
Topics:
Wright, Stephen W.
Li, Bryan
Peng, Zhihui
Wei, Lulin
McInturff, Emma
Place, David
Damon, David B.
Singer, Robert A.
An improved process for the large scale synthesis of 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (1), a candidate currently in clinical development, was developed. Key objectives were to eliminate chro
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Doi:10.1007/BF00481613
()Doi:10.1002/hlca.19960790508
(1996)Doi:10.1080/00397919908086428
(1999)Doi:10.1016/0040-4039(96)01217-8
(1996)Doi:10.1021/ol0499203
(2004)Doi:10.1007/s00044-009-9202-z
(2010)