Medicinal Chemistry Research p. 403 - 412 (2010)
Update date:2022-08-03
Topics:
Zhang, Xue-Wu
Zhao, Dong-Hai
Quan, Ying-Chun
Sun, Liang-Peng
Yin, Xiu-Mei
Guan, Li-Ping
In an effort to develop potent antiinflammatory agents, a series of substituted chalcone derivatives was synthesized and evaluated for antiinflammatory activity through monitoring of their ability to inhibit xylene-induced ear edema in mice. Some of the tested compounds exhibited significant activity, and compounds 3f [(E)-1-(2,4-dihydroxyphenyl)-3-(4- dimethylamino)phenyl)prop-2-en-1-one] and 3h [(E)-3-(4-chlorophenyl)-1-(2,4- dihydroxyphenyl)prop-2-en-1-one] showed the highest antiinflammatory activity (62 and 68% inhibition, respectively, 2 h before administration), comparable with or even slightly more potent than the reference drug ibuprofen (53%). Furthermore, the structure-activity relationship of these substituted chalcone derivatives was demonstrated.
View MoreShanDong XinDa Chemical CO.,LTD(expird)
Contact:086-0311-87580543
Address:No.168, High Technology Development Zone Jinan Shandong China
Contact:+86-512-69561895
Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
Contact:+86-28-88523492
Address:714rooms of Time Square, Pujiang County
Rugao Jinling Chemical Co., Ltd.(expird)
Contact:0086-513-68005586
Address:Lianluo new village huangshi town Rugao city Jiangsu Province.
Liao Cheng All Win Chemicals Co.,LTD
Contact:86+0635-2991582
Address:Room 402,Unit 1,No.27 building.Zhong tong shi dai haoyuan,liaocheng city,Shan dong Province.China
Doi:10.1016/0040-4020(96)00731-4
(1996)Doi:10.1007/s10593-018-2368-x
(2018)Doi:10.1002/cber.19961291113
(1996)Doi:10.1016/S0040-4039(97)01235-5
(1997)Doi:10.1139/v96-181
(1996)Doi:10.1002/hlca.19680510321
(1968)