Bioorganic and Medicinal Chemistry Letters p. 2087 - 2090 (1996)
Update date:2022-08-05
Topics:
Huang, Tien L.
Zhang, Qian
White, Angele T.
Queener, Sherry F.
Bartlett, Marilyn S.
Smith, James W.
Donkor, Isaac O.
A series of novel piperidine-linked aromatic diimidazolines (3-7) have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii drug, Pentamidine. These compounds significantly inhibited the growth of Pneumocystis carinii in culture at 1 μg/mL.
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