SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor

Article abstract of DOI:10.1016/S0960-894X(99)00365-0

Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4- methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.