Bioorganic and Medicinal Chemistry Letters p. 2207 - 2212 (1999)
Update date:2022-08-05
Topics:
Leblanc
Roy
Boyce
Brideau
Chan
Charleson
Gordon
Grimm
Guay
Leger
Li
Riendeau
Visco
Wang
Webb
Xu
Prasit
Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4- methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.
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Doi:10.1039/a903160j
(1999)Doi:10.1021/acs.joc.7b02943
(2018)Doi:10.1016/0009-3084(79)90067-7
(1979)Doi:10.1021/ja01507a001
(1960)Doi:10.1016/S0040-4039(99)01265-4
(1999)Doi:10.1016/j.saa.2014.06.099
(2015)
