SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor

DOI: 10.1016/S0960-894X(99)00365-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2207 - 2212 (1999)

Update date:2022-08-05

Topics:

Authors:

Leblanc Leblanc

Roy Roy

Boyce Boyce

Brideau Brideau

Chan Chan

Charleson

Gordon Gordon

Grimm Grimm

Guay Guay

Leger Leger

Riendeau

Visco Visco

Wang Wang

Webb Webb

Prasit Prasit

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Article abstract of DOI:10.1016/S0960-894X(99)00365-0

Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4- methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.

Full text of DOI:10.1016/S0960-894X(99)00365-0

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Product name:cyclopropoxy-acetic acid 2-(4-methanesulfonyl-phenyl)-1,1-dimethyl-2-oxo-ethyl ester

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