The first chemical synthesis of wortmannin by starting from hydrocortisone

DOI: 10.1016/0040-4039(96)01332-9

Source and publish data:

Tetrahedron Letters p. 6141 - 6144 (1996)

Update date:2022-08-04

Topics:

Authors:

Sato, Seiji

Nakada, Masahisa

Shibasaki, Masakatsu

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Article abstract of DOI:10.1016/0040-4039(96)01332-9

The first chemical synthesis of wortmannin, a potent and specific inhibitor of PI 3-kinases, was achieved by starting from commercially available and optically pure hydrocortisone.

Full text of DOI:10.1016/0040-4039(96)01332-9

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