Synthesis of 1-(isoxazol-3-yl)triazene derivatives. Antimetastatic activity of 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene

Article abstract of DOI:10.1016/0223-5234(96)85884-3

The synthesis of some 3,3-dialkyl-1-(isoxazol-3-yl)triazenes is reported, together with preliminary biological tests on 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene 3a. This compound exerts a selective antimetastatic action in mice bearing Lewis lung carcinoma, reducing the weight but not the number of metastases. Some unfavorable properties in the toxicological profile of 3a have discouraged further investigation of this class of compounds.