Macrocycle formation by ring-closing-metathesis. 2. An efficient synthesis of enantiomerically pure (R)-(+)-lasiodiplodin

Article abstract of DOI:10.1016/0040-4039(96)01590-0

A highly efficient and flexible route to the macrolide (R)-(+)-lasiodiplodin 1 and its de-O-methyl congener 2 is outlined, which is based on the formation of the 12-membered ring by ring-closing metathesis (RCM) as the key step.