
Tetrahedron Letters p. 5921 - 5924 (1996)
Update date:2022-08-05
Topics:
Suzuki, Katsuhiko
Fujii, Takashi
Sato, Ken-Ichi
Hashimoto, Hironobu
Two routes for the synthesis of the amidine-linked pseudo-disaccharide were developed. The amidine linkage was constructed by the intermolecular or intramolecular coupling between thioamide and amine in the presence of mercury (II) chloride. The former construction from D-arabinono-1,5-thiolactam and 6-amino-6-deoxy-D-glucoside gave the corresponding pseudo-disaccharide. The latter construction of the amidine linkage was demonstrated in the case of 4-(5-amino-5-deoxy-D-thioarabinononyl)amino-4-deoxy-D-glucoside.
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