Two efficient routes for construction of amidine-linked pseudo-disaccharide

Article abstract of DOI:10.1016/0040-4039(96)01277-4

Two routes for the synthesis of the amidine-linked pseudo-disaccharide were developed. The amidine linkage was constructed by the intermolecular or intramolecular coupling between thioamide and amine in the presence of mercury (II) chloride. The former construction from D-arabinono-1,5-thiolactam and 6-amino-6-deoxy-D-glucoside gave the corresponding pseudo-disaccharide. The latter construction of the amidine linkage was demonstrated in the case of 4-(5-amino-5-deoxy-D-thioarabinononyl)amino-4-deoxy-D-glucoside.